Apples for Health- Cancer-Causing Gene Activity is Detailed

Cancer-Causing Gene Activity is Detailed

U.S. medical scientists have detailed the activity of gene named JAK that's closely related to a common cancer-causing gene in humans.

University of Rochester Medical Center researchers discovered JAK disrupts the activity of an organism's DNA on a broad scale, thwarting a critical molecular event very early during embryonic development.

By manipulating the DNA of fruit flies and analyzing their body types as they develop as maggots, the team discovered the cancer-promoting effects of a mutation to the DNA sequence of a gene that normally suppresses cancer can be passed from parents to offspring, even if the mutation itself isn't passed to the offspring.

Under some circumstances, having one parent with the mutation is enough to affect the offspring, even when the mutation itself is not passed to the next generation, the researchers said.

The study that included Associate Professor Willis Li, graduate students Yalan Xing and Song Shi; former postdoctoral fellow Dr. Long Le, technician Crystal Lee; and post-doctoral researcher Louise Silver-Morse is reported in the journal PLoS Genetics.

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