A U.S.-British study has determined the molecular process by which lymphomas develop.

   Researchers from the University of Pennsylvania and the Wistar Institute in Philadelphia, along with Oxford University scientists, identified the process used by the PAX5 protein that promotes the growth of common lymphomas.

   Researchers found PAX5 stimulates the growth of cancerous tumors by spurring cell division normally observed during B cell immune response. They said PAX5 "hijacks" the body's own defense system designed to multiply antibody-making B cells exposed to foreign antigens.

   The scientists said their discovery might lead to a new cancer treatment target.

   The study is reported in the September issue of The Journal of Clinical Investigation.

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