NAC boosts liver failure survival
LONDON, Jan. 3 (UPI) -- British researchers say children treated with N-acetylcysteine (NAC) for acute liver failure have better recovery and survival rates.
A report in the journal Liver Transplantation said NAC, a common antidote to acute liver failure from acetaminophen poisoning, has been found to be a successful treatment for children with non-acetaminophen induced acute liver failure.
Researchers led by Christine Kortsalioudaki of King's College Hospital in London examined the medical records of 170 children who came to the hospital with non-acetaminophen induced acute liver failure between 1989 and 2004. Those treated before 1994 were not treated with NAC, while those who came after 1995 did receive NAC.
The children who received NAC spent fewer days in intensive care, and 43 percent survived with their native liver, compared to 22 percent of children who did not receive NAC.
"Our data demonstrates that NAC has minor, self-limited adverse effects and can be safely administered to children with non-acetaminophen induced acute liver failure," the report said.
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