Apples for Health- No Effective Meds for Acute Heart Failure

No Effective Meds for Acute Heart Failure

GLASGOW, Scotland, Nov. 8 (UPI) -- A Scottish study shows available medications do not appear to improve symptoms or outcomes for patients suffering acute heart failure.

Researchers at the Western Infirmary in Glasgow found tezosentan -- a drug thought to fight the disease -- did not improve breathlessness or reduce the risk of fatal or non-fatal cardiovascular events.

Dr. John McMurray and colleagues tested tezosentan in two randomized trials that involved 1,435 patients at sites in Australia, Europe, Israel, and North America.

The researchers found tezosentan did not improve dyspnea more than placebo in either trial. The incidence of death or worsening heart failure at seven days was 26 percent in each treatment group, and up to 30 days was 32 percent in the tezosentan group and 33 percent in the placebo group.

"In summary, tezosentan, a treatment with 'favorable' hemodynamic actions, failed to improve breathlessness or reduce fatal and non-fatal cardiovascular events in patients following an emergency admission to hospital with acute heart failure.

"So far, it has proved impossible to identify a therapeutic role for endothelin antagonists in patients with acute or chronic heart failure," the researchers said.

The study appears in the Journal of the American Medical Association.
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