Volume 1, Number 18 - October 1, 1999
DHEA Helps Women With Adrenal Problems


 DHEA, a steroid hormone that has been hyped as a miracle drug to prevent aging, can help women with adrenal insufficiency increase their sex drive, according to a new study in the Friday issue of the New England Journal of Medicine. 

   The study by several German hospitals found that DHEA, or dehydroepiandrosterone, improves the well-being and sexuality of women with adrenal insufficiencies. It is not clear whether DHEA offers similar benefits for men. 

   The adrenal glands, located above the kidneys, produce hormones, including DHEA. DHEA is the most common weak male steroid hormone found in the bodies of both men and women. 

   "Our findings suggest that dehydroepiandrosterone should become part of the hormone-replacement regimen in women with adrenal insufficiency," writes Dr. Wiebke Arlt, lead author of the study and an endocrinologist at Medical University Hospital in Wuerzburg, Germany. 

   It still is unclear how DHEA works in humans. The researchers gave 50 milligrams of DHEA and a placebo to 24 women. They found that those taking DHEA showed a significant increase in their frequency of sexual thoughts, sexual interest, and satisfaction with the mental and physical aspects of their sexuality. 

   The researchers said DHEA likely has a direct effect on the nervous system, an increase in the synthesis of peripheral androgen (a male sex hormone), or both. 
  "Their findings are not surprising," said Dr. Robert Lahita, chief of rheumatology at St. Vincent's Hospital in New York. "DHEA improves the well-being and sex drive in the elderly. And it has few side effects." 

   Lahita said DHEA deficiencies affect the immune system and cognition. While DHEA has been heralded by some as an anti-aging medication, there is no evidence it works to prevent aging, he said. 

   According to the American Arthritis Foundation, DHEA occurs naturally in mammals. A mild androgen produced by the adrenal glands, DHEA is used by the body to make other hormones, such as testosterone and estrogen.  Some people take DHEA supplements, which come from extracts of wild Mexican yams, to relieve pain, inflammation or fatigue. 

   In an editorial accompanying the new study, Dr. Wolfgang Oelkers, a physician at Klinikum Benjamin Franklin in Berlin, cautions about overusing DHEA. 

   Oelkers said, "At present, there is justification for administering dehydroepiandrosterone to patients with adrenal insufficiency, but there is no justification for its administration to healthy elderly people." 

   Lahita also cautioned against taking DHEA supplements, which are available in health food stores, without advice from a physician. 

   "Androgen is a hormone that is converted to estrogen, so people taking too much of it run an increased risk of breast cancer or prostate cancer. It also can make you develop blood clots," Lahita said. 

   (Written by Lori Valigra in Cambridge, Mass.) 
Copyright 1999 by United Press International 
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